COVID-19 Variant Network – Innovative therapeutic approaches for the 2019-novel coronavirus

Boivin, Guy | $100,000

Quebec CHU de Québec 2021 CIHR Operating Grant


The 2019-novel coronavirus (SARS CoV-2) is a major sanitary and economical threat to all countries. Development of effective antivirals is a major global priority especially early in the epidemic when vaccines are unavailable. This proposal aims at discovering and evaluating active compounds by rational design through 3D modeling of key viral proteins and also by analyzing cellular gene signatures induced by the virus. In-depth evaluation of selected compounds will include in vitro, ex vivo (human bronchial epithelium tissues) and in vivo (animal models) studies. These approaches, mostly based on drug repurposing (new indication for an existing drug), will result in rapid identification of anti-SARS CoV-2 compounds with accelerated clinical development.

With funding from the Government of Canada

Please complete this short survey to help us understand our impact. Thank you!

Give Feedback